Revolutionizing Aneurysm Treatment: 4D Organogel Microcoils Successfully Tested in Rabbits

Date:05-12-2023   |   【Print】 【close

A research team led by Prof. XU Tiantian from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences, in collaboration with their peers, has introduced 4D ultraviolet (UV)-curable organogel microcoils with adaptive shapes for personalized embolization. 

The findings were published in Advanced Materials on November 14. 

Endovascular embolization using microcoils proves to be an effective technique for treating artery aneurysms, a concealed and potentially fatal vascular disease. However, microcoils with fixed designs face challenges in adapting to various aneurysm types. 

In this study, the researchers presented a photocurable ultratough shape memory organogel with a rapid curing time of only 2 seconds. Subsequently, they utilized this material to craft personalized 4D microcoils with a wire diameter as small as 0.3 mm, closely resembling the wire diameter of metallic microcoils. 

In comparison to natural hydrogels with high water content and photocurable hydrogels, the proposed organogel addresses issues of fragility and brittleness, demonstrating an improved modulus/strength, escalating from kilopascal to megapascal levels (511.63 MPa). This enhancement reduces the risk of microcoil fractures during embolization. Moreover, the organogel exhibits a fast body-temperature-triggered shape memory ability, enabling the 4D microcoil's applicability in vivo. 

These 4D microcoils were successfully deployed into rabbits, effectively obstructing blood flow in different aneurysms. Neoendothelial cells and collagen fibers grew snugly on the microcoil surface, indicating complete aneurysm recovery. 

"In the future, our 4D organogel microcoil holds the potential for clinical translation in humans. Its adaptable shape for different aneurysms could resolve the issues associated with current microcoils having fixed shapes," stated Prof. XU. 

Figure 1. Illustration of 4D microcoils for personalized endovascular embolization on rabbit model. (Image by SIAT)

Figure 2. Demonstration of in vitro embolization on round, flat, long, and dysmorphic aneurysms. (Image by SIAT)

Media Contact:
ZHANG Xiaomin