SIAT Research
-
Jan 28, 2026AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapyAAVLINK allows flexible gene segmentation design, achieves high-efficiency full-length gene reconstitution, and markedly reduces the production of aberrant truncated proteins compared with conventi... Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying gene cargoes because of their superior gene segmentation flexibility and... -
Jan 22, 2026Knowledge-Driven Autonomous Materials Research via Collaborative Multi-Agent and Robotic SystemIn a study published in Matter, a research team led by Prof.YU Xuefeng from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences developed a knowledge-driven mul... Traditional process to discover new materials is complex, time-consuming, and costly, which often requires years of a sustained effort. Recent advances in large language models (LLMs) have demonstr... -
Jan 19, 2026Composite Superionic Electrolytes for Pressure-less Solid-State Batteries Achieved by Continuously Perpendicularly Aligned 2D PathwaysIn a study published in Nature Nanotechnology, a team led by Prof. CHENG Hui-Ming and PENG Jing from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, along with Pr... Solid electrolytes are promising candidates for safe, high-energy battery systems. Composite solid electrolytes, in particular, hold the potential to combine high ionic conductivity with stable ele... -
Jan 14, 2026Amino Acid Residue-driven Nanoparticle Targeting of Protein Cavities Beyond Size ComplementarityIn a study published in the Journal of the American Chemical Society, led by Prof. LI Yang at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, elucidated the molecular m... Cavities at protein-protein interaction interfaces are often considered "undruggable" because their shallow or large geometries hinder the stable binding by small molecules. A study published in Jo... -
Jan 12, 2026New AI Algorithm Enables Scientific Monitoring of "Blue Tears"In a study published in Ecological Informatics, a team led by Prof. LI Jianping from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, along with the collaborators ... In recent years, "blue tears" chasing has become a popular tourism activity along coasts to witness the spectacular natural phenomenon. However, the occurrence and movement of algal blooms are unpr... -
Jan 09, 2026Overcoming Drug Resistance by Disrupting HDAC1 Condensates in GlioblastomaResearchers discovered that TMZ treatment induces the formation of HDAC1-CTCF condensates in GBM cells, leading to chromatin remodeling and enhanced DNA repair activity, thereby promoting acquired ... Glioblastoma (GBM) is one of the most common and aggressive primary brain tumors in adults, with an extremely poor prognosis and a median overall survival typically less than two years. Temozolomid... -
Dec 31, 2025Researchers Reveal High-Fat Diet-Induced Dysfunction in Lateral Septum That Exacerbates ObesityThe study discovered that activation of the lateral septum inhibits hedonic feeding, acting as a "brake system" in the brain's feeding regulation network and serving as a potential target for obesi... The prevalence of overweight and obesity is largely driven by the widespread availability of high-calorie and highly palatable foods. Even without feeling hungry, some people tend to eat food for t... -
Dec 29, 2025Active-Navigation, Stiffness-Tunable Microrobots for Precise Biopsy and Targeted Delivery in Narrow Luminal InterventionsThe team developed a microrobotic system based on a helix-shaped magnetic soft microrobot, the Helixoft. Surgical tasks in small tortuous lumens demand interventional instruments with controllable mechanical adaptability. However, current microcatheters lack a non-disruptive, integration-ready strateg...