SIAT Research
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Sep 02, 2025An AI-Driven Atomic Force Microscopy Platform for Decoding Human Immune Cell MechanicsIn this study, an integrated artificial intelligence (AI)-atomic force microscopy (AFM) platform is introduced that enables label-free, mechanophenotyping of macrophages at single-cell resolution. Macrophages drive key immune processes—including inflammation, tissue repair, and tumorigenesis—via distinct polarization states (e.g., M0, M1, M2), whose accurate identification is vital for dia... -
Aug 18, 2025Researchers Develop Multimodal Deep Learning Model to Enhance Precision Radiotherapy Decision-MakingResearchers developed a deep learning-based multimodal prognostic model that shows strong potential to improve disease-free survival prediction and enable personalized treatment in locally advanced... Cervical cancer is a major public health concern that poses a significant threat to women's health worldwide. While standard concurrent chemoradiotherapy (CCRT) achieves disease-free survival (DFS)... -
Aug 11, 2025Novel Biological Signal-Processing Framework Precisely Decodes Complex Cellular LanguageThis study introduces a framework that integrates orthogonal operational amplifiers into standardized biological processes to enable efficient signal decomposition and amplification. Cells naturally process external signals through intricate genetic circuits, enabling adaptation to diverse environments. These circuits rely on complex, nonlinear interactions among genes and prot... -
Aug 07, 2025First Evidence that Lifelong Oral Nicotine Shapes Motor and Metabolic Aging in MiceThis study offers a mechanistic framework for evaluating long‑term nicotine exposure and inspire the future development of "non‑addictive cholinergic metabolic modulators". As global populations age, preserving mobility and metabolic resilience has become a central challenge for healthy aging. Aging is a systemic process marked by energy imbalance and organ‑specific ... -
Jul 29, 2025Researchers Develop Bacterial Cellulose-Based Dressing for Advanced Burn Wound CareThis study develops a thrombin-anchored bacterial cellulose (T-BC) dressing for advanced burn care, enabling rapid and sustained hemostasis while preserving the structural and hydration benefits of... Recently, a research team led by Dr. ZHONG Chao and Dr. AN Bolin from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, collaborating with Dr. LIU Yan from Ruijin H... -
Jul 22, 2025Researchers Develop New Microscope for Neurovascular Coupling ImagingThe study presents a linear transducer array–based hybrid microscope that integrates photoacoustic microscopy and confocal fluorescence microscopy to enable simultaneous neurovascular imaging. The... Neurovascular coupling (NVC) is the dynamic regulation of cerebral blood flow in response to neural activity. Specifically, when neurons become active, nearby blood vessels dilate to increase blood... -
Jul 18, 2025Researchers Develop Microlens-Augmented AFM for Real-Time Nanoscale Observation and Control
This paper presents a nanomanipulation approach enabled by real-time super-resolution imaging guidance. Atomic force microscopy (AFM) is a cornerstone technique for nanoscale manipulation, enabling critical applications in nanoparticle assembly, biomolecule handling, semiconductor device manufacturin... -
Jul 08, 2025Deep Learning-based Model Enables Fast and Accurate Stroke Risk PredictionIn this study, an automated method for lumen, vessel wall, and plaque segmentation for quantitative assessment based on MR vessel wall images and a CNN model with different priors was developed and... Stroke is the second leading cause of death globally. Ischemic stroke, strongly linked to atherosclerotic plaques, requires accurate plaque and vessel wall segmentation and quantification for defin...