SIAT Research
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Jan 28, 2026AAVLINK: A potent DNA-recombination method for large cargo delivery in gene therapyAAVLINK allows flexible gene segmentation design, achieves high-efficiency full-length gene reconstitution, and markedly reduces the production of aberrant truncated proteins compared with conventi... Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying gene cargoes because of their superior gene segmentation flexibility and... -
Jan 22, 2026Knowledge-Driven Autonomous Materials Research via Collaborative Multi-Agent and Robotic SystemIn a study published in Matter, a research team led by Prof.YU Xuefeng from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences developed a knowledge-driven mul... Traditional process to discover new materials is complex, time-consuming, and costly, which often requires years of a sustained effort. Recent advances in large language models (LLMs) have demonstr... -
Jan 12, 2026From Chasing to Measuring: New AI Algorithm Enables Scientific Monitoring of “Blue Tears”Researchers developed an innovative real-time video monitoring algorithm named BT-YOLO. In recent years, "blue tears" chasing has become a popular tourism activity along coasts such as Pingtan, drawing large crowds eager to witness the spectacular natural phenomenon. However, the unpr... -
Jan 09, 2026Overcoming Drug Resistance by Disrupting HDAC1 Condensates in GlioblastomaResearchers discovered that TMZ treatment induces the formation of HDAC1-CTCF condensates in GBM cells, leading to chromatin remodeling and enhanced DNA repair activity, thereby promoting acquired ... Glioblastoma (GBM) is one of the most common and aggressive primary brain tumors in adults, with an extremely poor prognosis and a median overall survival typically less than two years. Temozolomid... -
Dec 31, 2025Researchers Reveal High-Fat Diet-Induced Dysfunction in Lateral Septum That Exacerbates ObesityThe study discovered that activation of the lateral septum inhibits hedonic feeding, acting as a "brake system" in the brain's feeding regulation network and serving as a potential target for obesi... The prevalence of overweight and obesity is largely driven by the widespread availability of high-calorie and highly palatable foods. Even without feeling hungry, some people tend to eat food for t... -
Dec 29, 2025Active-Navigation, Stiffness-Tunable Microrobots for Precise Biopsy and Targeted Delivery in Narrow Luminal InterventionsThe team developed a microrobotic system based on a helix-shaped magnetic soft microrobot, the Helixoft. Surgical tasks in small tortuous lumens demand interventional instruments with controllable mechanical adaptability. However, current microcatheters lack a non-disruptive, integration-ready strateg... -
Dec 22, 2025Premating Maternal Stress Induces Sex-Specific Emotional ChangesThe study uncovered how psychological stress experienced by mothers before conception may shape the long-term emotional behaviors of their offspring and revealed a previously unrecognized brain–bo... Women experience mood disorders at disproportionately high rates, and maternal emotional disturbances around pregnancy are known to increase children's vulnerability to neurodevelopmental and psych... -
Dec 11, 2025Scientists Develop Novel "Super-sensitive, Low-burden" Mammalian Cell-cell Communication SystemThe study revealed the small-molecule signaling system for mammalian cell-cell communication that combines super-sensitivity with a chassis-friendly, low-burden design, and demonstrated the system'... Cell-cell communication, as the "conductor" of physiological activities, transmits information through signaling molecules, coordinating development, immunity, and homeostasis. During embryonic con...