SIAT Research
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Sep 18, 2025Researchers Develop First "Dynamic" Soft Electrode for Brain-Computer InterfacesInspired by earthworms, the study introduces NeuroWorm—a soft, stretchable and movable fibre sensor designed for bioelectronic interface. In brain-computer interfaces (BCIs) and other neural implant systems, electrodes serve as the critical interface and are core sensors linking electronic devices with biological nervous systems. Mos... -
Sep 12, 2025Structural Insights into Acarbose Degradation Guide Next-Gen Antidiabetic Drug DesignThis study provides structural insights that inform the design and development of next-gen antidiabetic drug. Type 2 diabetes mellitus (T2DM), a chronic metabolic disorder marked by hyperglycemia, is rapidly becoming a major global health challenge. Acarbose is a potent glycosidase inhibitor widely used in... -
Sep 09, 2025Targeting "Aged" Immune Cells: A New Strategy to Boost Immunotherapy in Solid TumorsThis study provides valuable insights into the variability of tumor immune microenvironment across individuals and highlights the potential to enhance antitumor efficacy by targeting immunosenescence. Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor originating from the epithelial cells of the head and neck region. As a neoadjuvant treatment for locally advanced HNSCC, chemoimm... -
Sep 02, 2025An AI-Driven Atomic Force Microscopy Platform for Decoding Human Immune Cell MechanicsIn this study, an integrated artificial intelligence (AI)-atomic force microscopy (AFM) platform is introduced that enables label-free, mechanophenotyping of macrophages at single-cell resolution. Macrophages drive key immune processes—including inflammation, tissue repair, and tumorigenesis—via distinct polarization states (e.g., M0, M1, M2), whose accurate identification is vital for dia... -
Aug 18, 2025Researchers Develop Multimodal Deep Learning Model to Enhance Precision Radiotherapy Decision-MakingResearchers developed a deep learning-based multimodal prognostic model that shows strong potential to improve disease-free survival prediction and enable personalized treatment in locally advanced... Cervical cancer is a major public health concern that poses a significant threat to women's health worldwide. While standard concurrent chemoradiotherapy (CCRT) achieves disease-free survival (DFS)... -
Aug 11, 2025Novel Biological Signal-Processing Framework Precisely Decodes Complex Cellular LanguageThis study introduces a framework that integrates orthogonal operational amplifiers into standardized biological processes to enable efficient signal decomposition and amplification. Cells naturally process external signals through intricate genetic circuits, enabling adaptation to diverse environments. These circuits rely on complex, nonlinear interactions among genes and prot... -
Aug 07, 2025First Evidence that Lifelong Oral Nicotine Shapes Motor and Metabolic Aging in MiceThis study offers a mechanistic framework for evaluating long‑term nicotine exposure and inspire the future development of "non‑addictive cholinergic metabolic modulators". As global populations age, preserving mobility and metabolic resilience has become a central challenge for healthy aging. Aging is a systemic process marked by energy imbalance and organ‑specific ... -
Jul 29, 2025Researchers Develop Bacterial Cellulose-Based Dressing for Advanced Burn Wound CareThis study develops a thrombin-anchored bacterial cellulose (T-BC) dressing for advanced burn care, enabling rapid and sustained hemostasis while preserving the structural and hydration benefits of... Recently, a research team led by Dr. ZHONG Chao and Dr. AN Bolin from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences, collaborating with Dr. LIU Yan from Ruijin H...