SIAT Research
-
Mar 11, 2024Scientists Develop Efficient Method for Reshaping Yeast DNAThis work sheds light on the high plasticity of rDNA organization and paves the way for the future rDNA engineering. Chinese scientists, along with their international counterparts from the University of Manchester, have developed a method called construction of a repetitive array by transformation (CAT) for effi... -
Mar 06, 2024Researchers Develop High-Performance MXene/Polydopamine Bioelectrodes, Paving the Way for Cost-Effective Bioelectronics"Our bioelectrodes demonstrate a remarkable reduction in cost," said Prof. ZHANG Yi, "It holds great promise for the utilization of new-generation bioelectronic interfaces in both research and clin... The ideal bioelectronic interfaces typically necessitate bioelectrodes that fulfill practical requirements, including low interface impedance, exceptional long-term stability, and biosafety.However... -
Mar 05, 2024Unlocking Cellular Mysteries: Advancements in Single-Cell Omics Analysis with Genome-Scale Metabolic ModelingWhile GEMs are mainly used to analyze single-cell RNAseq data, with the development of single-cell proteomics and metabolomics, it is believed that GEM-aided analysis of multi-omics of single cells... The widespread applications of single-cell technologies have generated a large amount of single-cell data, resulting in a growing need for methods for single-cell data analysis and interpretation. ... -
Mar 05, 2024Researchers Develop Dynamic Model Integrating Protein Allocation with Flux Balance AnalysisThis work provides a quantitative tool to investigate cellular metabolism under varying environments and reveals insights into bacterial adaptation strategies. Recently, a research team led by Prof. FU Xiongfei from the Shenzhen Institute of Advanced Technology of Chinese Academy of Sciences has developed a dynamic model integrating protein allocation wit... -
Mar 04, 2024Enhanced Minimally Invasive Implantation: 4D Printed Hydrogel Scaffold with Programmable Deformation and Swelling-Stiffening PropertiesThis study presentes a novel and promising approach for minimally invasive treatment of tissue defects, which shows potential in biomedical applications. Recently, researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences have developed an approach to deliver scaffolds in a minimally invasive manner thr... -
Feb 28, 2024Innovating Pathway Engineering at the Crossroads of IT and BT: A Novel Strategy for Overcoming Genetic Constraints"Heterologous pathway engineering has become a crucial aspect of biosynthesis," stated Prof. LOU. "We warmly welcome long-term postdoctoral researchers with backgrounds in biology, chemistry, bioin... Pathway engineering faces a critical challenge: genes' evolutionary potential and adaptability are limited by epistatic effects, causing uncertainty and sluggish evolution. For example, a small twe... -
Feb 28, 2024New Neuromodulation Strategy Clears Alzheimer's Pathological Proteins, Reveals Potential Treatment AvenueThe research team's data reveal independent microglia-mediated phagocytosis pathways toward Aβ and synapses. Our results also shed light on a synergistic strategy of depolarizing microglia and inh... Recently, Professor ZHAN Yang 's team at the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences unveiled a novel neuromodulation strategy targeting microglia. Their... -
Feb 04, 2024Programmable Aptasensor for Regulating CRISPR/Cas12a ActivityThe CPAS platform exhibited high sensitivity for S protein and ATP detection. Integration with a lateral flow assay enabled sensitive detection within 1 h, revealing its excellent potential for por... The clustered regularly interspaced short palindromic repeats (CRISPR) system, with advantages of simple manufacturing, portability, and high specificity, has been developed extensively and applied...