SIAT Research
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Mar 04, 2024Enhanced Minimally Invasive Implantation: 4D Printed Hydrogel Scaffold with Programmable Deformation and Swelling-Stiffening PropertiesThis study presentes a novel and promising approach for minimally invasive treatment of tissue defects, which shows potential in biomedical applications. Recently, researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences have developed an approach to deliver scaffolds in a minimally invasive manner thr... -
Feb 28, 2024Innovating Pathway Engineering at the Crossroads of IT and BT: A Novel Strategy for Overcoming Genetic Constraints"Heterologous pathway engineering has become a crucial aspect of biosynthesis," stated Prof. LOU. "We warmly welcome long-term postdoctoral researchers with backgrounds in biology, chemistry, bioin... Pathway engineering faces a critical challenge: genes' evolutionary potential and adaptability are limited by epistatic effects, causing uncertainty and sluggish evolution. For example, a small twe... -
Feb 28, 2024New Neuromodulation Strategy Clears Alzheimer's Pathological Proteins, Reveals Potential Treatment AvenueThe research team's data reveal independent microglia-mediated phagocytosis pathways toward Aβ and synapses. Our results also shed light on a synergistic strategy of depolarizing microglia and inh... Recently, Professor ZHAN Yang 's team at the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences unveiled a novel neuromodulation strategy targeting microglia. Their... -
Feb 04, 2024Programmable Aptasensor for Regulating CRISPR/Cas12a ActivityThe CPAS platform exhibited high sensitivity for S protein and ATP detection. Integration with a lateral flow assay enabled sensitive detection within 1 h, revealing its excellent potential for por... The clustered regularly interspaced short palindromic repeats (CRISPR) system, with advantages of simple manufacturing, portability, and high specificity, has been developed extensively and applied... -
Feb 04, 2024Time-Sequential and Multi-Functional 3D Printed Scaffold Provides Strategies for Postsurgical Osteosarcoma Treatment"Our strategy has great potential for clinical applications in postsurgical OS treatment," said Prof. LAI. Osteosarcoma (OS) is a primary bone malignant tumor. The current clinical standard treatment for OS comprises a combination of neoadjuvant chemotherapy and surgical resection. However, the clinical... -
Feb 01, 2024Novel Injectable Hydrogel Dressing for Treating Diabetic WoundsThe study provided a promising strategy for the clinical treatment of diabetic wounds, as well as the therapy of oxidative stress related diseases. Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences have developed an antioxidative bioactive glass reinforced injectable hydrogel possessing du... -
Jan 19, 2024Scientists Slow Light Down In Metasurfaces With Record Low LossThe innovative design proposed by the researchers holds promise for unprecedented photon manipulation with greater flexibility and potential applications in slow-light photonic chips. The speed of light in a vacuum is an absolute limit, but it can be intentionally reduced in various media. Slowing down light offers numerous advantages, making it easier to manipulate and enhancin... -
Jan 19, 2024"Knowledge + Data" Driven AIGC in Brain Image Computing For Alzheimer's Disease AnalysisBy modeling a complex multilevel mapping of structure-function-morphology information, PALH significantly enhances Alzheimer's disease diagnosis performance and identifies relevant connectivity pat... Generative AI finds a valuable application in the realm of brain network analysis, utilizing deep learning to generate a patient's brain network from multimodal images. However, existing data-drive...