SIAT Research
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Feb 04, 2024Programmable Aptasensor for Regulating CRISPR/Cas12a ActivityThe CPAS platform exhibited high sensitivity for S protein and ATP detection. Integration with a lateral flow assay enabled sensitive detection within 1 h, revealing its excellent potential for por... The clustered regularly interspaced short palindromic repeats (CRISPR) system, with advantages of simple manufacturing, portability, and high specificity, has been developed extensively and applied... -
Feb 04, 2024Time-Sequential and Multi-Functional 3D Printed Scaffold Provides Strategies for Postsurgical Osteosarcoma Treatment"Our strategy has great potential for clinical applications in postsurgical OS treatment," said Prof. LAI. Osteosarcoma (OS) is a primary bone malignant tumor. The current clinical standard treatment for OS comprises a combination of neoadjuvant chemotherapy and surgical resection. However, the clinical... -
Feb 01, 2024Novel Injectable Hydrogel Dressing for Treating Diabetic WoundsThe study provided a promising strategy for the clinical treatment of diabetic wounds, as well as the therapy of oxidative stress related diseases. Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences have developed an antioxidative bioactive glass reinforced injectable hydrogel possessing du... -
Jan 19, 2024Scientists Slow Light Down In Metasurfaces With Record Low LossThe innovative design proposed by the researchers holds promise for unprecedented photon manipulation with greater flexibility and potential applications in slow-light photonic chips. The speed of light in a vacuum is an absolute limit, but it can be intentionally reduced in various media. Slowing down light offers numerous advantages, making it easier to manipulate and enhancin... -
Jan 19, 2024"Knowledge + Data" Driven AIGC in Brain Image Computing For Alzheimer's Disease AnalysisBy modeling a complex multilevel mapping of structure-function-morphology information, PALH significantly enhances Alzheimer's disease diagnosis performance and identifies relevant connectivity pat... Generative AI finds a valuable application in the realm of brain network analysis, utilizing deep learning to generate a patient's brain network from multimodal images. However, existing data-drive... -
Jan 17, 2024Revolutionizing Cancer Treatment: Novel Strategy for Anti-Tumor Immunotherapy Based on NanogelsThe proposed co-delivery system (denoted as D&E@NG) was constructed by linking Dia-PEG on the outer surface of NG via an azo bond, while loading EGCG within the cavity of NGs. A research group led by Prof. LI Yang at the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences has successfully developed a hypoxia-responsive nanogel (NG) for the... -
Jan 09, 2024The Cytosolic Aminotransferase VAS1 Coordinates Aromatic Amino Acid Biosynthesis and MetabolismThe researchers identify a cytosolic aromatic aminotransferase, REVERSAL OF SAV3 PHENOTYPE 1 (VAS1), as a suppressor of arogenate dehydrogenase 2 (adh2) in Arabidopsis (Arabidopsis thaliana). Aromatic amino acids (AAAs) play a crucial role not only in the synthesis of proteins across all living cells but also in the generation of various primary and specialized metabolites. In the realm... -
Dec 22, 2023Researchers Develop an Innovative Weakly Supervised Learning Method for Cell Detection and Tracking Using Incomplete Initial AnnotationsThe proposed methods are promising and open up new avenues for efficient cell analysis in various biological applications. A research group led by Prof. WEI Yanjie from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences and their collaborators have proposed an effective deep learnin...