SIAT Research
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Jan 09, 2026Overcoming Drug Resistance by Disrupting HDAC1 Condensates in GlioblastomaResearchers discovered that TMZ treatment induces the formation of HDAC1-CTCF condensates in GBM cells, leading to chromatin remodeling and enhanced DNA repair activity, thereby promoting acquired ... Glioblastoma (GBM) is one of the most common and aggressive primary brain tumors in adults, with an extremely poor prognosis and a median overall survival typically less than two years. Temozolomid... -
Dec 31, 2025Researchers Reveal High-Fat Diet-Induced Dysfunction in Lateral Septum That Exacerbates ObesityThe study discovered that activation of the lateral septum inhibits hedonic feeding, acting as a "brake system" in the brain's feeding regulation network and serving as a potential target for obesi... The prevalence of overweight and obesity is largely driven by the widespread availability of high-calorie and highly palatable foods. Even without feeling hungry, some people tend to eat food for t... -
Dec 29, 2025Active-Navigation, Stiffness-Tunable Microrobots for Precise Biopsy and Targeted Delivery in Narrow Luminal InterventionsThe team developed a microrobotic system based on a helix-shaped magnetic soft microrobot, the Helixoft. Surgical tasks in small tortuous lumens demand interventional instruments with controllable mechanical adaptability. However, current microcatheters lack a non-disruptive, integration-ready strateg... -
Dec 22, 2025Premating Maternal Stress Induces Sex-Specific Emotional ChangesThe study uncovered how psychological stress experienced by mothers before conception may shape the long-term emotional behaviors of their offspring and revealed a previously unrecognized brain–bo... Women experience mood disorders at disproportionately high rates, and maternal emotional disturbances around pregnancy are known to increase children's vulnerability to neurodevelopmental and psych... -
Dec 11, 2025Scientists Develop Novel "Super-sensitive, Low-burden" Mammalian Cell-cell Communication SystemThe study revealed the small-molecule signaling system for mammalian cell-cell communication that combines super-sensitivity with a chassis-friendly, low-burden design, and demonstrated the system'... Cell-cell communication, as the "conductor" of physiological activities, transmits information through signaling molecules, coordinating development, immunity, and homeostasis. During embryonic con... -
Dec 05, 2025Global 10m Resolution PV Power Plant Dataset (2019-2025): A Breakthrough via ANDPI and Multi-Source Data FusionThe study developed a 10-meter resolution global dataset of centralized photovoltaic (PV) power plants. As one of the most promising renewable energy technologies worldwide, photovoltaic (PV) power plays a pivotal role in achieving carbon neutrality, and accurately locating PV power plants and tracki... -
Dec 03, 2025CEST-MRI Study Develops Joint Motion–Intensity Correction Framework for Enhanced Quantitative ImagingThe study developed the motion–intensity joint correction framework specifically tailored to CEST-MRI. Chemical Exchange Saturation Transfer (CEST) MRI is a molecular imaging approach that can sensitively probe tissue metabolism and microenvironment through frequency-selective saturation and exchang... -
Dec 02, 2025Bacteroides fragilis Activates a Cholinergic Gut–Brain Circuit to Suppress SeizuresThe study reveals how Bacteroides fragilis activates a previously unrecognized cholinergic gut–vagus–brain circuit and demonstrates its therapeutic potential in both animal models and children wi... In a study published in Neuron on January 16, a research team led by Prof. LIU Xin'an and Prof. CHEN Zuxin from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Scienc...