SIAT Research
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Dec 02, 2025Bacteroides fragilis Activates a Cholinergic Gut–Brain Circuit to Suppress SeizuresThe study reveals how Bacteroides fragilis activates a previously unrecognized cholinergic gut–vagus–brain circuit and demonstrates its therapeutic potential in both animal models and children wi... In a study published in Neuron on January 16, a research team led by Prof. LIU Xin'an and Prof. CHEN Zuxin from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Scienc... -
Nov 28, 2025Exploring Functional Insights into the Human Gut Microbiome via the Structural ProteomeThis study established a structural proteome database and structure-based retrieval framework for the human gut microbiome, significantly improving the ability to predict functional "dark matter" s... Despite rapid advances in microbiome research, a large proportion of proteins encoded by the human gut microbiome remain functionally uncharacterized. Sequence-based methods often fail to annotate ... -
Nov 20, 2025New Intraoperative SERS Navigation System Enables Real-Time Malignancy Grading of Prostate TumorsResearch team has developed a label-free intraoperative navigation system based on surface-enhanced Raman scattering (SERS) that enables real-time, in situ grading of prostate tumor malignancy by s... Precise identification of tumor boundaries during radical prostatectomy remains a major clinical challenge, with positive surgical margins occurring in 15–40% of prostate cancer cases, significant... -
Nov 20, 2025Scientists Reveals "Source-Sink" Mechanisms and Ecological Drivers of Carbon Sequestration in the Greater Bay AreaA "scientific diagnosis report" on the estuarine carbon cycle. The coastal ecosystems of the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) faces pressure from high-intensity anthropogenic activities, making the high-resolution scientific assessment of its c... -
Nov 18, 2025Scientists Identify a Key Neuron-Derived Driver of Neurovascular Injury After StrokeThis work has uncovered a previously unknown neuronal signalling mechanism that amplifies brain injury after ischaemic stroke. For ischaemic stroke patients, although revascularisation therapies such as intravenous thrombolysis and mechanical thrombectomy restore blood flow, many of them still experience secondary haemorrh... -
Nov 17, 2025Researchers develop a multi-modal vision-language model for generalizable annotation-free pathology localizationThis work developed a generalizable vision-language model for Annotation-Free pathology Loclization (AFLoc), which demonstrates superior performance in localizing pathologies and supporting diagnos... Accurate localization of pathologies in medical images is crucial for precise diagnosis and effective treatment. While deep learning has greatly advanced medical image analysis, most existing model... -
Nov 17, 2025Target binding of black phosphorus nanomaterial to polo-like kinase 1 for cancer chemotherapy: a mutual selection of nanomaterial and proteinThis work uncovered how black phosphorus nanomaterials (BPNMs) recognize and bind a key cell cycle regulator, polo like kinase 1 (PLK1). Understanding how nanomaterials interact with biological macromolecules is essential for advancing nanomedicine. Over the past two decades, the "protein corona" concept has guided research into nan... -
Nov 17, 2025Whole-Body PET/CT Study Maps Inter-Organ Metabolic Networks Across the Glycemic SpectrumThis research uncovered how metabolic coordination among major organs shifts across normal glycemia, prediabetes, and diabetes. Diabetes is now understood to be a systemic metabolic disorder, involving disruptions across multiple organs rather than a single glycemic pathway. Yet, in clinical practice, metabolic health is st...